Brusatol: A potential anti-tumor quassinoid from Brucea javanica

作者：Xiao‐Qi Yu, Xin‐Yue Shang, Xiao‐Xiao Huang, Guo‐Dong Yao, Shao‐Jiang Song · 发表于：Chinese Herbal Medicines · 年份：2020 · DOI：10.1016/j.chmed.2020.05.007 · 被引用次数：36 · 研究领域：Phytochemical compounds biological activities、Histone Deacetylase Inhibitors Research、Synthesis and biological activity

Brusatol, a triterpene lactone compound mainly from Brucea javanica, sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo. This review also covers pharmacokinetics studies, modification of dosages forms of brusatol. Increasing evidences have validated the value of brusatol as a chemotherapeutic agent in cancers, which may contribute to drug development and clinical application.