Differences in atheroma between Caucasian and Asian subjects with anterior stroke: A vessel wall MRI study

作者：Hiroko Watase, Mi Shen, Binbin Sui, Peiyi Gao, Dong Zhang, Jie Sun, Niranjan Balu, Daniel S. Hippe, Gail P. Jarvik, Xihai Zhao, Rui Li, Shuo Chen, Chun Yuan, Thomas S. Hatsukami · 发表于：Stroke and Vascular Neurology · 年份：2020 · DOI：10.1136/svn-2020-000370 · 被引用次数：14 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Intracranial Aneurysms: Treatment and Complications、Moyamoya disease diagnosis and treatment

BACKGROUND AND PURPOSE: While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians, the differences in atherosclerotic plaque characteristics have not yet been extensively examined. We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI. METHODS: Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols. Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics. RESULTS: The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1% and 49.1%, respectively (p=0.055). Prevalence of intracranial plaque was 38.5% and 69.1% in Caucasians and Chinese, respectively (p=0.02). Furthermore, 42% of Caucasians and 16% of Chinese had high-risk plaque (HRP) features (intraplaque haemorrhage, luminal surface disruption) in the extracranial carotid artery (p=0.03). The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts (4% vs 11%; p=0.42). CONCLUSIONS: Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke. Extracranial carotid plaques ...