Biocatalysis of MnO 2 -Mediated Nanosystem for Enhanced Multimodal Therapy and Real-Time Tracking

作者：Xiaowei Li, Xiaoyu Zhang, Xiaoyu Zhang, Weidong Zhang, Lei Li, Wenbin Gao, Xuwu Zhang, Xuwu Zhang, Dawei Gao · 发表于：ACS Sustainable Chemistry & Engineering · 年份：2020 · DOI：10.1021/acssuschemeng.0c02367 · 被引用次数：35 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Cancer, Stress, Anesthesia, and Immune Response

Clearance of endogenous glutathione (GSH) to cytotoxic hydroxyl radicals ( • OH) and insufficient cellular hydrogen peroxide (H 2 O 2 ) limited the efficacy of chemodynamic therapy (CDT) to a tumor. Herein, a biocompatible nanosystem has been developed to overcome the dilemma of CDT; first, soya lecithin, paclitaxel, MnO 2 nanoparticles, and glucose oxidase (GOx) were self-assembled to PTX/MnO 2 /GOx-Lips and then hyaluronic acid (HA) was modified on the surface of nanosystem to enhance tumor targeting. MnO 2 consumed the endogenous GSH to generate Mn 2+, which relieved the clearance of • OH and enhanced the CDT effect; meanwhile, Mn 2+ -mediated magnetic resonance imaging (MRI) also can provide the track of prepared nanosystem in vivo synchronously. Furthermore, the O 2 generated from the CDT process promoted starving-like therapy, which, in turn, provided more H 2 O 2 for intensifying CDT. The final tumor inhibition effect was nearly 93.92% in tumor-bearing mice. Therefore, our design solved the long-standing limitation of CDT and showed excellent antitumor efficacy, which also achieved the highly efficient synergy of CDT, starving-like therapy, chemotherapy, and real-time tracking. The study makes a great contribution to the development of CDT, even in the field of cancer treatment, which exhibits potential for clinic transformation.