Patient outcomes after hospitalisation with COVID-19 and implications for follow-up; results from a prospective UK cohort

作者：David Arnold, Fergus Hamilton, Alice Milne, A Morley, Jason Viner, Marie Attwood, Antoine Noël, Samuel Gunning, Janice Hatrick, Shea Hamilton, KT Elvers, Catherine Hyams, Anna Bibby, E. J. MORAN, Huzaifa Adamali, James Dodd, Nick Maskell, Shaney Barratt · 发表于：medRxiv · 年份：2020 · DOI：10.1101/2020.08.12.20173526 · 被引用次数：110 · 研究领域：Long-Term Effects of COVID-19、COVID-19 Clinical Research Studies、COVID-19 and Mental Health

ABSTRACT Background COVID-19 causes a wide spectrum of disease. The incidence and severity of sequelae after the acute infection is uncertain. Data measuring the longer-term impact of COVID-19 on symptoms, radiology and pulmonary function are urgently needed to plan follow-up services. Methods Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study with outcomes recorded at 28-days. All were invited to a systematic follow up at 8-12 weeks, including chest radiograph, spirometry, exercise test, bloods, and health-related quality of life (HRQoL) questionnaires. Findings Between 30 th March and 3 rd June 2020, 163 patients with COVID-19 were recruited. Median hospital length of stay was 5 days (IQR 2-8) and 19 patients died. At 8-12 weeks post admission, 134 patients were available for follow up and 110 attended. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) with reduced HRQoL. Only patients who required oxygen therapy in hospital had abnormal radiology, clinical examination or spirometry at follow up. Thirteen (12%) patients had an abnormal chest X-ray with improvement in all but 2 from admission. Eleven (10%) had restrictive spirometry. Blood test abnormalities had returned to baseline in the majority (104/110). Interpretation Patients with COVID-19 remain highly symptomatic at 8-12 weeks, however, clinical abnormalities requiring action are infrequent, especially in those without a supplement...