G6PD: A hub for metabolic reprogramming and redox signaling in cancer

作者：Hung‐Chi Yang, Arnold Stern, Daniel T. Chiu · 发表于：Biomedical Journal · 年份：2020 · DOI：10.1016/j.bj.2020.08.001 · 被引用次数：96 · 研究领域：Neonatal Health and Biochemistry、Cancer, Hypoxia, and Metabolism、Childhood Cancer Survivors' Quality of Life

Metabolic hubs play a major role in the initiation and development of cancer. Oncogenic signaling pathways drive metabolic reprogramming and alter redox homeostasis. G6PD has potential oncogenic activity and it plays a pivotal role in cell proliferation, survival and stress responses. Aberrant activation of G6PD via metabolic reprogramming alters NADPH levels, leading to an antioxidant or a pro-oxidant environment which can either enhance DNA oxidative damage and genomic instability or initiate oncogenic signaling. Nutrient deprivation can rewire metabolism, which leads to mutations that determine a cancer cell's fate. Deregulated G6PD status and oxidative stress form a vicious cycle, which paves the way for cancer progression. This review aims to update and focus the potential role of G6PD in metabolic reprogramming and redox signaling in cancer.