Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and T H 17 responses

作者：Youhui Si, Qiaomu Tian, Fan Zhao, Sean H. Kelly, Lucas Shores, Daniel F. Camacho, Anne I. Sperling, Michael S. Andrade, Joel H. Collier, Anita S. Chong · 发表于：Science Advances · 年份：2020 · DOI：10.1126/sciadv.aba0995 · 被引用次数：47 · 研究领域：Immunotherapy and Immune Responses、RNA Interference and Gene Delivery、Inhalation and Respiratory Drug Delivery

17 cells occurring independently in both LN and lung. Thus, self-assembling peptide nanofiber vaccines may represent a novel, needle- and adjuvant-free means of eliciting protective immunity against fungal and bacterial infections at skin and mucosal barrier surfaces.