Relationship between iron status markers and insulin resistance: an exploratory study in subjects with excess body weight

作者：M. Pilar Vaquero, Daniel Martínez‐Maqueda, Angélica Gallego‐Narbón, Bélen Zapatera, Jara Pérez‐Jiménez · 发表于：PeerJ · 年份：2020 · DOI：10.7717/peerj.9528 · 被引用次数：21 · 研究领域：Iron Metabolism and Disorders、Hemoglobinopathies and Related Disorders、Erythropoietin and Anemia Treatment

Background Controversy exists on the relationship between iron metabolism and cardiometabolic risk. The aim of this study was to determine if there is a link between dysmetabolic iron and cardiometabolic markers in subjects with excess body weight. Methods Cross-sectional study with fifty participants presenting overweight or obesity and at least another metabolic syndrome factor. Determinations: anthropometry, body composition, blood pressure, lipids, glucose, insulin, leptin, areas under the curve (AUC) for glucose and insulin after an oral glucose tolerance test, hs-C reactive protein (hs-CRP), blood count, ferritin, transferrin, transferrin saturation (TSAT), soluble transferrin receptor (sTfR). Gender-adjusted linear correlations and two independent samples t tests were used. Results Ferritin was positively correlated with insulin-AUC ( r = 0.547, p = 0.008) and TSAT was negatively correlated with waist-hip ratio ( r = − 0.385, p = 0.008), insulin ( r = − 0.551, p < 0.001), and insulin resistance (HOMA-IR, r = − 0.586, p < 0.001). Subjects with TSAT ≤ 20% had higher insulin ( p = 0.012) and HOMA-IR ( p = 0.003) compared to those with TSAT > 20%. In conclusion, the observed results suggest that iron transport and storage are altered in subjects with overweight/obesity, at the same time that they exhibit the characteristic features of insulin resistance. Nevertheless, this occurs without iron overload or deficiency. These results should be validated in wider cohor...