Phenoxazine‐based Near‐infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells

作者：Yang Shen, Wubin Zheng, Yusi Yao, Dongmei Wang, Guanglei Lv, Chunxia Li · 发表于：Chemistry - An Asian Journal · 年份：2020 · DOI：10.1002/asia.202000783 · 被引用次数：41 · 研究领域：Molecular Sensors and Ion Detection、Luminescence and Fluorescent Materials、Advanced biosensing and bioanalysis techniques

Abstract Abstract : It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are “turn‐off” probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel “turn‐on” near‐infrared (NIR) fluorescent probe PZ‐N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu 2+ ). Upon the addition of Cu 2+ , the probe could quickly react with Cu 2+ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ‐N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ‐N was capable of effectively detecting Cu 2+ in living cells.