Microglia and astrocyte dysfunction in parkinson's disease

作者：Tae‐In Kam, Jared T. Hinkle, Ted M. Dawson, Valina L. Dawson · 发表于：Neurobiology of Disease · 年份：2020 · DOI：10.1016/j.nbd.2020.105028 · 被引用次数：402 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Nuclear Receptors and Signaling、Parkinson's Disease Mechanisms and Treatments

While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.