Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

作者：Andrew Rhodes, Laura Evans, Waleed Alhazzani, Mitchell M. Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan Sevransky, Charles L. Sprung, Mark Nunnally, Bram Rochwerg, Gordon D. Rubenfeld, Derek C. Angus, Djillali Annane, Richard Beale, Geoffrey J. Bellinghan, Gordon R. Bernard, Jean‐Daniel Chiche, Craig Coopersmith, Daniel De Backer, Craig French, Seitaro Fujishima, Herwig Gerlach, Jorge Hidalgo, Steven M. Hollenberg, Alan E. Jones, Dilip R. Karnad, Ruth Kleinpell, Younsuck Koh, Thiago Lisboa, Flávia Ribeiro Machado, John J. Marini, John C. Marshall, John E. Mazuski, Lauralyn McIntyre, Anthony S. McLean, Sangeeta Mehta, Rui P. Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M. Osborn, Anders Perner, Colleen M. Plunkett, Marco Ranieri, Christa Schorr, Maureen A. Seckel, Christopher W. Seymour, Lisa Shieh, Khalid Shukri, Steven Q. Simpson, Mervyn Singer, Bruce Thompson, Sean R. Townsend, T. van der Poll, Jean‐Louis Vincent, W. Joost Wiersinga, Janice L. Zimmerman, R. Phillip Dellinger · 发表于：Critical Care Medicine · 年份：2017 · DOI：10.1097/ccm.0000000000002255 · 被引用次数：3813 · 研究领域：Sepsis Diagnosis and Treatment、Nosocomial Infections in ICU、Immune Response and Inflammation

OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012." DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. METHODS: The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable. RESULTS: The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were we...