Single-Cell Analyses Identify Dysfunctional CD16+ CD8 T Cells in Smokers

作者：Suzanne N. Martos, Michelle R. Campbell, Oswaldo A. Lozoya, Xuting Wang, Brian D. Bennett, Isabel J. B. Thompson, Ma Wan, Gary S. Pittman, Douglas A. Bell · 发表于：Cell Reports Medicine · 年份：2020 · DOI：10.1016/j.xcrm.2020.100054 · 被引用次数：45 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Immunotherapy and Immune Responses

) cells. Indicative of immune aging, smokers' CD8 T cells are biased toward differentiated cells and smokers have fewer naïve cells than nonsmokers. DNA methylation-based models show that smoking dose is associated with accelerated aging and decreased telomere length, a biomarker of T cell senescence. Immune aging accompanies T cell senescence, which can ultimately lead to impaired immune function. This suggests a role for smoking-induced, senescence-associated immune dysregulation in smoking-mediated pathologies.