Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p

作者：Bing Xia, Jianbo Gao, Shengyou Li, Liangliang Huang, Lei Zhu, Teng Ma, Laihe Zhao, Yujie Yang, Kai Luo, Xiaowei, Shi, Liangwei Mei, Hao Zhang, Yi Zheng, Lei Lü, Zhuojing Luo, Jinghui Huang · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.44912 · 被引用次数：113 · 研究领域：Extracellular vesicles in disease、Nerve injury and regeneration、RNA Interference and Gene Delivery

Our findings suggested that mechanical stimuli are capable of modulating the intercellular communication between neurons and SCs by altering miRNA composition in MS-SCs-EVs. Transfer of miR-23b-3p by MS-SCs-EVs from mechanically stimulated SCs to neurons decreased neuronal Nrp1 expression, which was responsible, at least in part, for the beneficial effect of MS-SCs-EVs on axonal regeneration. Our results highlighted the potential therapeutic value of MS-SCs-EVs and miR-23b-3p-enriched EVs in peripheral nerve injury repair.