Yeast Cell wall Particle mediated Nanotube-RNA delivery system loaded with miR365 Antagomir for Post-traumatic Osteoarthritis Therapy via Oral Route

作者：Long Zhang, Peng Hang, Wan Zhang, Yankun Li, Liang Liu, Tongtong Leng · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.46761 · 被引用次数：50 · 研究领域：Osteoarthritis Treatment and Mechanisms、RNA Interference and Gene Delivery、Knee injuries and reconstruction techniques

Here, we constructed a biodegradable drug delivery system based on non-pathogenic YCWP and nanotubes, which can be used for PTOA therapy via the oral route. It suggests a new gene therapy strategy with YCWP mediated oral nano drug delivery system may serve as a platform for joint degeneration treatment.