Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China

作者：Duantao Cao, Ruilin Wu, Suxia Dong, Feiyan Wang, Chao Ju, Sumei Yu, Shiji Xu, Hua Fang, Yunlong Yu · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2020 · DOI：10.1128/aac.00904-20 · 被引用次数：22 · 研究领域：Antifungal resistance and susceptibility、Infectious Diseases and Mycology、Entomopathogenic Microorganisms in Pest Control

A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in A. fumigatus from soil samples.