Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance

作者：Jie Sun, Wei Yan, Xingnan Zhang, Xiao Lin, Hui Li, Yi-Miao Gong, Xi-Mei Zhu, Yongbo Zheng, Xiangyang Guo, Yundong Ma, Zeng-Yi Liu, Lin Liu, Jia‐Hong Gao, Michael V. Vitiello, Suhua Chang, Xiaoguang Liu, Lin Lü · 发表于：Translational Psychiatry · 年份：2020 · DOI：10.1038/s41398-020-00941-z · 被引用次数：35 · 研究领域：Pain Management and Placebo Effect、Heart Rate Variability and Autonomic Control、Diet and metabolism studies

Abstract Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In this study, we combined 1206 participants with phenotype data, resting-state functional magnetic resonance imaging (rfMRI) data and genotype data from the Human Connectome Project and two large sample size genome-wide association studies (GWASs) summary data from published studies to identify the genetic and neural bases for the association between pain and sleep disturbance. Pittsburgh sleep quality index (PSQI) score was used for sleep disturbance, pain intensity was measured by Pain Intensity Survey. The result showed chronic pain was significantly correlated with sleep disturbance ( r = 0.171, p -value < 0.001). Their genetic correlation was r g = 0.598 using linkage disequilibrium (LD) score regression analysis. Polygenic score (PGS) association analysis showed PGS of chronic pain was significantly associated with sleep and vice versa. Nine shared functional connectivity (FCs) were identified involving prefrontal cortex, temporal cortex, precentral/postcentral cortex, anterior cingulate cortex, fusiform gyrus and hippocampus. All these FCs mediated the effect of sleep disturbance on pain and seven FCs mediated the effect of pain on sleep disturbance. The chronic pain...