COVID-19

作者：Daniel S. Knight, Tushar Kotecha, Yousuf Razvi, Liza Chacko, James T. Brown, Paramjit S. Jeetley, James Goldring, Michael Jacobs, Lucy E. Lamb, Rupert Negus, Anthony Wolff, James C. Moon, Hui Xue, Peter Kellman, Niket Patel, Marianna Fontana · 发表于：Circulation · 年份：2020 · DOI：10.1161/circulationaha.120.049252 · 被引用次数：149 · 研究领域：COVID-19 Clinical Research Studies、Cardiac Arrest and Resuscitation、Long-Term Effects of COVID-19

◼ edema ◼ gadolinium ◼ magnetic resonance imaging ◼ myocarditis ◼ severe acute respiratory syndrome coronavirus 2 ◼ troponin H ospitalized patients with coronavirus disease 2019 (COVID-19) frequently have myocardial injury with troponin elevation, 1-4 but the underlying causes beyond acute coronary syndromes and pulmonary emboli are ill defined.We used cardiovascular magnetic resonance (CMR) during early convalescence to assess the presence, type, and extent of myocardial injury in troponin-positive patients with COVID-19.All patients with COVID-19 discharged from the Royal Free London NHS Foundation Trust until April 30, 2020 were reviewed (Figure).Diagnosis was either by (1) positive oro/nasopharyngeal throat swab for severe acute respiratory syndrome coronavirus 2 by reverse transcriptase polymerase chain reaction or (2) negative swabs for severe acute respiratory syndrome coronavirus 2 but the triad of viral illness symptoms (≥1 of cough, fever, myalgia), typical blood biomarkers (≥1 of new lymphopenia, high d-dimer, high ferritin, elevated liver transaminases), and probable likelihood of COVID-19 infection on thoracic imaging.A CMR scan (1.5T, Magnetom Aera, Siemens Healthcare) was offered to patients discharged with a COVID-19 diagnosis and myocardial injury as indicated by elevated high-sensitivity troponin T (hsTnT, >14 ng/L).Exclusions were hospitalization with acute coronary syndromes or pulmonary emboli, known cardiac pathology likely to cause scar, age ≥80 years, ...