Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials

作者：David A. Jolliffe, Carlos A. Camargo, John Sluyter, Mary Aglipay, John F. Aloia, Davaasambuu Ganmaa, Peter Bergman, Arturo Borzutzky, Camilla Trab Damsgaard, Gal Dubnov‐Raz, Susanna Esposito, Clare Gilham, Adit A. Ginde, Inbal Golan‐Tripto, Emma C Goodall, Cameron Charles Grant, Chris Griffiths, Anna Maria Hibbs, Wim Janssens, Anuradha Vaman Khadilkar, Ilkka Laaksi, Margaret T. Lee, Mark B Loeb, Jonathon L. Maguire, Paweł Majak, David T. Mauger, Semira Manaseki‐Holland, David R. Murdoch, Akio Nakashima, Rachel Ε. Neale, Hai D. Pham, Christine Rake, Judy R. Rees, Jenni Rosendahl, Robert K.R. Scragg, Dheeraj Shah, Yoshiki Shimizu, Steve Simpson, Geeta Trilok Kumar, Mitsuyoshi Urashima, Adrian R. Martineau · 发表于：medRxiv · 年份：2020 · DOI：10.1101/2020.07.14.20152728 · 被引用次数：104 · 研究领域：Vitamin D Research Studies、Vitamin C and Antioxidants Research、Chronic Obstructive Pulmonary Disease (COPD) Research

BACKGROUND: A 2017 meta-analysis of data from 25 randomised controlled trials of vitamin D supplementation for the prevention of acute respiratory infections revealed a protective effect of the intervention. Since then, 20 new RCTs have been completed. METHODS: Systematic review and meta-analysis of data from randomised controlled trials (RCTs) of vitamin D for ARI prevention using a random effects model. Pre-specified sub-group analyses were done to determine whether effects of vitamin D on risk of ARI varied according to baseline 25-hydroxyvitamin D (25[OH]D) concentration or dosing regimen. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and the ClinicalTrials.gov registry from inception to 1st May 2020. Double-blind RCTs of supplementation with vitamin D or calcidiol, of any duration, were eligible if they were approved by a Research Ethics Committee and if ARI incidence was collected prospectively and pre-specified as an efficacy outcome. Aggregate data, stratified by baseline 25(OH)D concentration, were obtained from study authors. The study was registered with PROSPERO (no. CRD42020190633). FINDINGS: We identified 45 eligible RCTs (total 73,384 participants). Data were obtained for 46,331 (98.0%) of 47,262 participants in 42 studies, aged 0 to 95 years. For the primary comparison of vitamin D supplementation vs. placebo, the intervention reduced risk of ARI overall (Odds Ratio [OR] 0.91, 95% CI 0.84 to 0.99; P f...