Lanostane tetracyclic triterpenoids as important sources for anti-inflammatory drug discovery

作者：Wei Wang, Yupei Yang, Shumaila Tasneem, Muhammad Daniyal, Liu Zhang, Yanzhe Jia, Yuqing Jian, Bin Li · 发表于：World Journal of Traditional Chinese Medicine · 年份：2020 · DOI：10.4103/wjtcm.wjtcm_17_20 · 被引用次数：26 · 研究领域：Natural product bioactivities and synthesis、Plant biochemistry and biosynthesis、Phytochemical compounds biological activities

Inflammation is a defensive reaction of the human body to numerous detrimental stimuli, including physical trauma, noxious chemicals, as well as microbial agents. Uncontrolled inflammation is the pathological basis of multiple diseases, such as rheumatoid arthritis (RA), neurodegenerative diseases, liver disease, and lung inflammation. Lanostane triterpenoids are natural tetracyclic triterpenoids with significant anti-inflammatory activity. An extensive review of the published literature regarding the phytochemistry and anti-inflammatory pharmacology of lanostane triterpenoids has been performed and analyzed using several search engines, such as SciFinder, Web of Science, Scopus, PubMed, Google Scholar, and ScienceDirect. This review is devoted to naturally occurring lanostane-type triterpenes with anti-inflammatory activity, including their sources, biosynthesis, and mechanism of action. This review also discusses the inflammation-related diseases and the clinical significance of traditional Chinese medicine as multi-target therapeutic agents for the prevention and treatment of inflammatory diseases. In the past 30 years, more than 100 new lanostane-type triterpenes have been reported from the families Schisandraceae, Ganodermataceae, and Polyporaceae. Six compounds, fomitopinic acid A, fomitosides E and F, obtusifoliol, 4α, l4α-dimethyl-5α-ergosta-7,9(11), 24(28)-trien-3 β-ol, and gramisterol exhibited the most potent anti-inflammatory activity against cyclooxygenase-1 (COX...