Crystalline Lens Power and Associated Factors in Highly Myopic Children and Adolescents Aged 4 to 19 Years

作者：Tianyu Cheng, Junjie Deng, Shuyu Xiong, Suqin Yu, Bo Zhang, Jingjing Wang, Wei Gong, Huijuan Zhao, Mengli Luan, Mengjun Zhu, Jianfeng Zhu, Haidong Zou, Xian Xu, Xiangui He, Xun Xu, Xun Xu, Xun Xu · 发表于：American Journal of Ophthalmology · 年份：2020 · DOI：10.1016/j.ajo.2020.07.007 · 被引用次数：29 · 研究领域：Ophthalmology and Visual Impairment Studies、Visual perception and processing mechanisms、Glaucoma and retinal disorders

PURPOSE: To investigate the distribution characteristics of lens power in highly myopic Chinese children and adolescents and its association with age, axial length (AL), and spherical equivalent (SE). DESIGN: Cross-sectional study. METHODS: A total of 459 highly myopic (SE ≤-5 diopter [D]) children and adolescents aged 4-19 years were included in the study. Participants underwent a series of ophthalmic examinations, which included AL, cycloplegic refraction, and Pentacam measurements. Lens power was calculated using Bennett's formula with its distribution described by age, AL, and SE. Multiple regression was conducted to analyze the associated factors of lens power. RESULTS: Greater lens power was independently associated with younger age, girls, shorter AL, and thicker lens thickness (standardized β = -0.203, 0.214, -0.379 and 0.492, respectively; all P < .001). However, a significant difference in lens power with age was only found in participants younger than 9 years, after which it reached a plateau (mean difference of 1.23 and 0.084 D per age group, respectively). Lens power was negatively associated with AL only in participants with AL <27 mm. No correlation was observed between lens power and SE. CONCLUSION: Among highly myopic children and adolescents, differences in lens power with age declined significantly after 9 years of age, which was 1 year earlier than non-high myopic patients in previous studies, which implied differences in pathophysiological process between...