Structure and function of HECT E3 ubiquitin ligases and their role in oxidative stress

作者：Hao Qian, Ying Zhang, Boquan Wu, Shaojun Wu, Shilong You, Naijin Zhang, Yingxian Sun · 发表于：Journal of Translational Internal Medicine · 年份：2020 · DOI：10.2478/jtim-2020-0012 · 被引用次数：52 · 研究领域：Ubiquitin and proteasome pathways、Cancer, Hypoxia, and Metabolism、Mitochondrial Function and Pathology

Ubiquitination is a modification after protein transcription that plays a vital role in maintaining the homeostasis of the cellular environment. The Homologous to E6AP C-terminus (HECT) family E3 ubiquitin ligases are a kind of E3 ubiquitin ligases with a C-terminal HECT domain that mediates the binding of ubiquitin to substrate proteins and a variable-length N-terminal extension. HECT-ubiquitinated ligases can be divided into three categories: NEDD4 superfamily, HERC superfamily, and other HECT superfamilies. HECT ubiquitin ligase plays an essential role in the development of many human diseases. In this review, we focus on the physiological and pathological processes involved in oxidative stress and the role of E3 ubiquitin ligase of the HECT family.