Role of anti-Müllerian hormone and testosterone in follicular growth: a cross-sectional study

作者：Pingping Lv, Min Jin, Jinpeng Rao, Jian Chen, Liquan Wang, Chang-Chang Huang, Songqing Yang, Qiuping Yao, Lei Feng, Jin‐Ming Shen, Chun Feng · 发表于：BMC Endocrine Disorders · 年份：2020 · DOI：10.1186/s12902-020-00569-6 · 被引用次数：48 · 研究领域：Ovarian function and disorders、Reproductive Biology and Fertility、Ovarian cancer diagnosis and treatment

Abstract Background Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian reserve (DOR) and polycystic ovarian syndrome (PCOS) as two extremes of ovarian reserve (deficient and excessive respectively) to investigate the role of AMH and sex hormones in follicular growth. Methods A retrospective cross-sectional survey was performed. The patients assessed AMH and basal sex hormones in the Second Hospital of Zhejiang University from April 2016 to March 2019 were involved in this study. Serum AMH and sex hormone concentrations were tested with electrochemiluminescence method. Stepwise linear regression and binary logistic regression was used to determine the predictors of AMH level and to explore the involved factors determining DOR and PCOS. Results In the present study, we found that age and follicle-stimulating hormone (FSH) were main negative correlation factors, and luteinizing hormone (LH) and testosterone (T) were main positive factors of AMH. In DOR group, age, FSH and estradiol (E 2 ) increased and T decreased, while in PCOS group, LH and T increased. Binary logistic regression found that age, weight, FSH, E 2 , and T were the significant factors which independently predicted the likelihood of DOR, and that age, body mass ...