Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg

作者：Yang Wang, Lili Zhang, Li Li, Hantong Hu, Pan Pan, Baoyu Zhang, Wenhua Ning, Mengxiong Zhao, Shu Wang · 发表于：Evidence-based Complementary and Alternative Medicine · 年份：2020 · DOI：10.1155/2020/5375981 · 被引用次数：10 · 研究领域：Stress Responses and Cortisol、Tryptophan and brain disorders、Circadian rhythm and melatonin

The present study investigated the effects of electroacupuncture on blood pressure in spontaneously hypertensive rats (SHRs) by regulating the immune balance of T helper 17 cells (Th17 cells) and regulatory T cells (Treg cells). This study investigated the role of electroacupuncture in the immune balance of SHRs using Western blot, flow cytometry, and ELISA techniques. Electroacupuncture significantly improved blood pressure, downregulated the expression of ROR γ t, and upregulated the expression of Foxp3, reduced the production of Th17 cells, promoted the production of Treg cells, reduced the secretion of IL‐6 and IL‐17, and increased the secretion of TGF‐ β 1 and IL‐10. These findings suggest that electroacupuncture therapy effectively improved the systolic blood pressure of SHRs, and its mechanism may be related to promotion of the immune balance between Th17 and Treg.