Patterns of Antiretroviral Therapy Use and Immunologic Profiles at Enrollment in the REPRIEVE Trial

作者：Carl J. Fichtenbaum, Heather J. Ribaudo, Jorge Leon-Cruz, Edgar T. Overton, Markella V. Zanni, Carlos Malvestutto, Judith A. Aberg, Emma M. Kileel, Kathleen V. Fitch, Marije Van Schalkwyk, Nagalingeswaran Kumarasamy, Esteban Martinez, Breno Santos, Yvetot Joseph, Janet Lo, Sue Siminski, Kathleen Melbourne, Craig A. Sponseller, Patrice Desvigne‐Nickens, Gerald S. Bloomfield, Judith S. Currier, Udo Hoffmann, Pamela S. Douglas, Steven Grinspoon, REPRIEVE Investigators, Adrián Curran, Adrienne Baranauskas, Aimee Wilkin, Alexandra Abrams-Downey, Allison Ross Eckard, Alysse G Wurcel, Ana Gonzalez‐Cordón, Armando Paez, Beverly E. Sha, Breno Santos, Carina Beppu Yoshida, Charlotte-Paige Rolle, Charurut Somboonwit, C. Funk, Cristina Gómez‐Ayerbe, Cynthia Frank, Daniel E. Nixon, Daniel J. Skiest, David Choi, David Mushatt, David Rial‐Crestelo, Deborah K Perez, Deirdre J Burke, Desirée V G dos Santos, Dushyantha Jayaweera, Edward M. Gardner, Edwin DeJesus, Elizabeth Connick, Emerline G Lam, Emily J. Hecker, Esper G Kallas, Esteban Martinez, E. T. Waters, Frank S. Rhame, Fred R. Sattler, Gary P Wang, Helen May Enrile Seedhom, Isabel Cristina Ferreira Tavares, Jack T Stapleton, Jaclyn Bennet, James B. Brock, James Scott, Janet Forcht, Javier R Lama, Javier Valencia, Jennifer K Brumfield, Jennifer K Brumfield, Joaquin Portilla, Jonathan Kumar, Jordi Navarro, Jorge Pinto, Jose G Castro, José Ignacio Bernardino, José L. Casado, José Valdez Madruga, Josu Baraia‐Etxaburu, Juan Berenguer, Judith A. Aberg, Judith S. Currier, Karen T. Tashima, Ken S. Ho, Laura V L Costa, Leire Pérez‐Latorre, Lerato Mohapi, L López-González, Lori E. Fantry, Lourdes Domínguez-Domínguez, Luz Martín‐Carbonero, Lynne Cornelissen, Mamta K. Jain, Mar Masiá, Marcus Lacerda, Maria Saumoy, Marije Van Schalkwyk, Marina Villalobos-Hernández, Mark Mall, Maureen Kubat, Melissa Carreres, Michael Frank, Michael J Kozal, Mireia de la Peña, Nadim Salomon, Nagalingeswaran Kumarasamy, Natapol Kosashunhanan, Ntebo D Mogashoa, Nwora Lance Okeke, Pamela G Mukwekwerere, Patcharaphan Sugandhavesa, Pilar Vizcarra, Princy Kumar, Renee Weinman, Richard M. Novak, Rina Chaudhary, Rodney Dawson, Roger Bedimo, Romina Chinchay, Sandy Pillay, Sara H Bares, Sharlaa Badal‐Faesen, Sharon Walmsley, Sigrid Perez-Frontera, Sondra Middleton, Stockton Mayer, Suzanne L Adams, Umesh Lalloo, Vicente Estrada, Vicky Watson, Victor Chiang, Adrián Curran, Adrienne Baranauskas, Aimee Wilkin, Alexandra Abrams-Downey, Allison Ross Eckard, Alysse G Wurcel, Ana Gonzalez‐Cordón, Armando Paez, Beverly E. Sha, Breno Santos, Carina Beppu Yoshida, Charlotte-Paige Rolle, Charurut Somboonwit, C. Funk, Cristina Gómez‐Ayerbe, Cynthia Frank, Daniel E. Nixon, Daniel J. Skiest, David Choi, David Mushatt, David Rial‐Crestelo, Deborah K Perez, Deirdre J Burke, Desirée V G dos Santos, Dushyantha Jayaweera, Edward M. Gardner, Edwin DeJesus, Elizabeth Connick, Emerline G Lam, Emily J. Hecker, Esper G Kallas, Estebán Martínez, E. T. Waters, Frank S. Rhame, Fred R. Sattler, Gary P Wang, Helen May Enrile Seedhom, Isabel Cristina Ferreira Tavares, Jack T Stapleton, Jaclyn Bennet, James B. Brock, James Scott, Janet Forcht, Javier R Lama, Javier Valencia, Jennifer K Brumfield, Jennifer K Brumfield, Joaquin Portilla, Jonathan Kumar, Jordi Navarro, Jorge Pinto, Jose G Castro, José Ignacio Bernardino, José L. Casado, José Valdez Madruga, Josu Baraia‐Etxaburu, Juan Berenguer, Judith A. Aberg, Judith S. Currier, Karen T. Tashima, Ken S. Ho, Laura V L Costa, Leire Pérez‐Latorre, Lerato Mohapi, L López-González, Lori E. Fantry, Lourdes Domínguez-Domínguez, Luz Martín‐Carbonero, Lynne Cornelissen, Mamta K. Jain, Mar Masiá, Marcus Lacerda, Maria Saumoy, Marije Van Schalkwyk, Marina Villalobos-Hernández, Mark Mall, Maureen Kubat, Melissa Carreres, Michael Frank, Michael J Kozal, Mireia de la Peña, Nadim Salomon, Nagalingeswaran Kumarasamy, Natapol Kosashunhanan, Ntebo D Mogashoa, Nwora Lance Okeke, Pamela G Mukwekwerere, Patcharaphan Sugandhavesa, Pilar Vizcarra, Princy Kumar, Renee Weinman, Richard M. Novak, Rina Chaudhary, Rodney Dawson, Roger Bedimo, Romina Chinchay, Sandy Pillay, Sara H Bares, Sharlaa Badal‐Faesen, Sharon Walmsley, Sigrid Perez-Frontera, Sondra Middleton, Stockton Mayer, Suzanne L Adams, Umesh Lalloo, Vicente Estrada, Vicky Watson, Victor Chiang · 发表于：The Journal of Infectious Diseases · 年份：2020 · DOI：10.1093/infdis/jiaa259 · 被引用次数：13 · 研究领域：HIV-related health complications and treatments、HIV/AIDS drug development and treatment、HIV Research and Treatment

BACKGROUND: Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, and contemporary trends are not well described. METHODS: The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human immunodeficiency virus (HIV) who were aged 40-75 years, receiving ART, and had low-to-moderate cardiovascular disease risk. ART use was summarized within Global Burden of Disease (GBD) super-regions, with adjusted linear and logistic regression analyses examining associations with immune parameters and key demographics. RESULTS: A total of 7770 participants were enrolled, with a median age of 50 years (interquartile range, 45-55 years); 31% were female, 43% were black or African American, 15% were Asian, 56% had a body mass index >25 (calculated as weight in kilograms divided by height in meters squared), and 49% were current or former smokers. The median CD4 T-cell count was 620/µL (interquartile range, 447-826/ µ L), and the median duration of prior ART use, 9.5 years (5.3-14.8) years. The most common ART regimens were nucleoside/nucleotide reverse-transcriptase inhibitor (NRTI) plus nonnucleoside reverse-transcriptase inhibitor (43%), NRTI plus integrase strand transfer inhibitor (25%), and NRTI plus protease inhibitor (19%). Entry ART varied by GBD region, with shifts during the trial enrollment period. In adjusted analyses, entry CD4 cell count and CD4/CD8 ratio were associated with GBD region, sex, entry regimen, durat...