The YAP/SERCA2a signaling pathway protects cardiomyocytes against reperfusion-induced apoptosis

作者：Jiankai Zhong, Haichun Ouyang, Sulin Zheng, Zhongzhou Guo, Yuying Chen, Yuan‐Lin Zhong, Wenhao Zhong, Liuer Zuo, Jianhua Lu · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.103481 · 被引用次数：21 · 研究领域：Hippo pathway signaling and YAP/TAZ、Cell death mechanisms and regulation、PARP inhibition in cancer therapy

overexpression on mitochondrial damage and ERS. Overall, our findings reveal that the YAP/SERCA2a pathway attenuates the mitochondrial damage and ERS in response to cardiac I/R injury by regulating the mitochondria-ER communication.