Finely tuned Prussian blue-based nanoparticles and their application in disease treatment

作者：Yong Gao, Guocan Yu, Kuoran Xing, Dmitry A. Gorin, Yuri Kotelevtsev, Weijun Tong, Zhengwei Mao · 发表于：Journal of Materials Chemistry B · 年份：2020 · DOI：10.1039/d0tb01248c · 被引用次数：40 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Metal-Organic Frameworks: Synthesis and Applications

The Prussian blue (PB) based nanostructure is a mixed-valence coordination network with excellent biosafety, remarkable photothermal effect and multiple enzyme-mimicking behaviours. Compared with other nanomaterials, PB-based nanoparticles (NPs) exhibit several unparalleled advantages in biomedical applications. This review begins with the chemical composition and physicochemical properties of PB-based NPs. The tuning strategies of PB-based NPs and their biomedical properties are systemically demonstrated. Afterwards, the biomedical applications of PB-based NPs are comprehensively recounted, mainly focusing on treatment of tumors, bacterial infection and inflammatory diseases. Finally, the challenges and future prospects of PB-based NPs and their application in disease treatment are discussed.