RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC

作者：Seong‐Jin Kim, Jin‐Sung Ju, Myoung Hee Kang, Ji Eun Won, Young Ha Kim, Prahlad V. Raninga, Kum Kum Khanna, Balázs Győrffy, Chan‐Gi Pack, Hee‐Dong Han, Hee Jin Lee, Gyungyub Gong, Yong Jae Shin, Gordon B. Mills, Seong‐il Eyun, Yun‐Yong Park · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.45037 · 被引用次数：75 · 研究领域：RNA Research and Splicing、RNA modifications and cancer、RNA and protein synthesis mechanisms

NONO is an RBP upstream regulator of both STAT3 RNA and protein levels and function. It represents an important and clinically relevant promoter of growth and resistance of TNBCs. NONO is also therefore a potential therapeutic target in TNBC.