Laxative Metabolites from the Leaves of Moringa oleifera

作者：Mengyuan Jiang, Huai Xiu Lu, Xiao-Yun Pu, Yanhong Li, Kai Tian, Yong Xiong, Wei Wang, Xiang‐Zhong Huang · 发表于：Journal of Agricultural and Food Chemistry · 年份：2020 · DOI：10.1021/acs.jafc.0c01564 · 被引用次数：28 · 研究领域：Moringa oleifera research and applications、Hibiscus Plant Research Studies

Three new flavonoids, quercetin-3- O -6-[methyl-( S )-3-hydroxy-3-methylglutaroyl(1→6]-β- d -glucopyranoside ( 1 ), kaempferol-3- O -[methyl-( S )-3-hydroxy-3-methylglutaroyl(1→6)]-β- d -glucopyranoside ( 2 ), and quercetin-3- O -6-[( E )-4-methoxy-5-methylhexa-2,4-dienoatyl(1→6)]-β- d -glucopyranoside ( 3 ), and two new alkaloids, 5-dehydroxymethyl-pyrrolemarumine 4″- O -α- l -rhamnopyranoside ( 4 ) and N 1 -methyl- N 2 -((4- O -α- l -rhamnopyranoside)benzyl) oxalamide ( 5 ), together with 45 known compounds ( 6 – 50 ) were isolated from the leaves of Moringa oleifera Lam. Among those compounds, 1-octacosanol ( 50 ), a straight-chain 28-carbon alcohol, exhibited good activity against diphenoxylate-induced constipation in mice, which is obtained as a laxative constituent from the plant for the first time. In order to have an accurate understanding of the content of compound 50, a quantification with gas chromatography–tandem mass spectrometry (GC–MS/MS) was carried out. The anti-inflammatory and α-glucosidase inhibitory activity of some compounds also was assessed.