Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP-1 formation

作者：Yuehua You, Wanying Tan, Yongzheng Guo, Minghao Luo, Fei‐Fei Shang, Yong Xia, Suxin Luo · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2020 · DOI：10.1152/ajpheart.00206.2020 · 被引用次数：39 · 研究领域：Estrogen and related hormone effects、Nitric Oxide and Endothelin Effects、Menopause: Health Impacts and Treatments

Progesterone directly upregulated endothelial nitric oxide synthase (eNOS) expression in human endothelial cells. Progesterone augmented eNOS promoter activity through a progesterone receptor A- and specificity protein-1-dependent manner. Antagonism of the progesterone receptor reduced eNOS expression and impaired vasodilation in rats.