Biodegradable reduction and pH dual-sensitive polymer micelles based on poly(2-ethyl-2-oxazoline) for efficient delivery of curcumin

作者：Hena Zhang, Xiaojun Liu, Ting Xu, Kang Xu, Baixiang Du, Yuling Li · 发表于：RSC Advances · 年份：2020 · DOI：10.1039/d0ra02779k · 被引用次数：19 · 研究领域：Nanoparticle-Based Drug Delivery、RNA Interference and Gene Delivery、Dendrimers and Hyperbranched Polymers

). The release behavior of PEtOx-SS-PLA 52 drug-loaded micelles in C6 cells showed that polymer micelle enhanced the intracellular release of Cur, and increased the inhibition effect of cancer cells. In a word, these reduction and pH-dual sensitive, biodegradable, hydrophilic shell-discarding PEtOx-SS-PLA micelles have great potential for future tumour administration.