The effectiveness of conservative interventions for the management of syndromic hypermobility: a systematic literature review

作者：Shea Palmer, Indi Davey, Laura Oliver, Amara Preece, Laura Sowerby, Sophie House · 发表于：Clinical Rheumatology · 年份：2020 · DOI：10.1007/s10067-020-05284-0 · 被引用次数：33 · 研究领域：Connective tissue disorders research、Hip disorders and treatments、Scoliosis diagnosis and treatment

INTRODUCTION: 'Syndromic hypermobility' encompasses heritable connective tissue disorders such as hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders which are characterised by excessive joint range of motion and pain. Conservative interventions such as exercise are the cornerstone of management, yet their effectiveness is unclear. AIM: To systematically appraise the effectiveness of conservative management for people with syndromic hypermobility. METHOD: A systematic online database search was conducted (AMED, BND, CINAHL Plus, MEDLINE, PEDro, PsychINFO and SportDiscus). Potential articles were assessed for eligibility by two researchers against the following criteria: adults and children with a hEDS/HSD diagnosis (or equivalent diagnosis using specific criteria); non-pharmacological or non-surgical interventions; outcomes related to pain, physical function, psychological well-being or quality of life. Controlled trials and cohort studies were included. Critical Appraisal Skills Programme checklists were used to assess methodological quality. RESULTS: Eleven studies were included, comprising eight controlled trials and three cohort studies. All studies investigated interventions that had exercise as the primary component. Three small controlled studies demonstrated superior effects of conservative management relative to a control group. However, those studies only focused on a single area of the body, only recruited women, and had no long-term follow-up. ...