Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients

作者：Ming Tong, Yu Jiang, Da Xia, Ying Xiong, Qing Zheng, Fang Chen, Lianhong Zou, Wen Xiao, Yimin Zhu · 发表于：The Journal of Infectious Diseases · 年份：2020 · DOI：10.1093/infdis/jiaa349 · 被引用次数：226 · 研究领域：COVID-19 Clinical Research Studies、Long-Term Effects of COVID-19、SARS-CoV-2 and COVID-19 Research

In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.