Metal–Organic Framework Derived Nanozymes in Biomedicine

作者：Dongdong Wang, Deblin Jana, Yanli Zhao · 发表于：Accounts of Chemical Research · 年份：2020 · DOI：10.1021/acs.accounts.0c00268 · 被引用次数：531 · 研究领域：Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications、Electrochemical sensors and biosensors

Nanozymes, which integrate the advantages of both nanomaterials and natural enzymes, have accumulated enormous research interest over the past decades because of the opportunity they provide to appreciate and further cultivate artificial enzymes with comparable properties. By mimicking the coordination environments of the catalytic sites in natural enzymes, nanozymes with confined nanostructures can serve as substitutes in many catalytic processes with comparable activity and robust stability even in harsh conditions. Since the pioneering report about peroxidase-mimicking ferromagnetic nanoparticles in 2007, nanozymes have been developed as specialized for nanomaterials with intrinsic enzyme-mimicking property. With the rapid development in nanoscience and nanotechnology, nanomaterials with superior advantages, such as large-scale production, desired activity, and robust stability, can bridge the natural enzymes with nanozymes.Metal-organic frameworks (MOFs) and their derivatives hold great promise to serve as direct surrogates of conventional enzymes for enzymatic reactions. According to their chemical nature, MOF-based nanozymes can be divided into three main categories: pristine MOFs, enzyme-encapsulated MOF composites, and MOF-based derivatives. Due to the versatility of metallic nodes and bridging linkers together with the feasibility of postsynthetic engineering and modification, MOFs and their derivatives are envisioned as one of the most appropriate surrogates for thi...