Early High Cerebrospinal Fluid Glutamate: A Potential Predictor for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

作者：Hongbin Wang, Qingjian Wu, Shijun Zhao, Ya‐Jun Hou, Jianhua Li, Mingfeng Yang, Baojun Wang, Baoliang Sun, Zongyong Zhang · 发表于：ACS Omega · 年份：2020 · DOI：10.1021/acsomega.0c01472 · 被引用次数：15 · 研究领域：Intracranial Aneurysms: Treatment and Complications、Traumatic Brain Injury and Neurovascular Disturbances、Cerebrospinal fluid and hydrocephalus

Delayed cerebral ischemia (DCI) is an important complication after aneurysmal subarachnoid hemorrhage (aSAH). Early identification of cerebrospinal fluid (CSF) markers is helpful for warning of impending DCI. This study assessed whether early high CSF glutamate levels can be observed in aSAH patients who later developed DCI. In this prospective clinical study, patients with normal pressure hydrocephalus or aSAH were enrolled. We found that the early CSF levels of glutamate were significantly elevated in aSAH patients compared to patients with normal pressure hydrocephalus. There was a significant difference in early CSF levels of glutamate between aSAH patients without DCI and with DCI. The early CSF levels of glutamate are significantly related to the Hunt and Hess grade, the World Federation of Neurological Surgeons (WFNS) grade, and the modified Fisher score on admission and occurrence of DCI in aSAH patients. Preliminary evidence of this study suggests that early high CSF glutamate levels are correlated with DCI in aSAH patients.