Synthesis and Absolute Configuration of Habiterpenol

作者：Miyuki Konya, Kenta Shimoyama, Shiho Arima, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda, Tohru Nagamitsu · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c01736 · 被引用次数：17 · 研究领域：Cancer Treatment and Pharmacology、Natural product bioactivities and synthesis、Biological Activity of Diterpenoids and Biflavonoids

The synthesis of habiterpenol, a G2 checkpoint inhibitor, was achieved through the stereoselective Ti(III)-mediated radical cyclization of a β-epoxide as the key reaction. Moreover, the absolute configuration of habiterpenol was determined.