Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy

作者：Emmanouil Papasavvas, Livio Azzoni, Brian N. Ross, Matthew Fair, Zhe Yuan, Kwasi Gyampoh, Agnieszka Mackiewicz, Amanda Sciorillo, Amélie Pagliuzza, Steven M. Lada, Guoxin Wu, Shih Lin Goh, Carolyn Bahnck-Teets, Daniel Holder, Paul Zuck, Mohammad Damra, Kenneth Lynn, Pablo Tebas, Karam Mounzer, Jay R. Kostman, Mohamed Abdel‐Mohsen, Douglas D. Richman, Nicolas Chomont, Bonnie J. Howell, Luis J. Montaner · 发表于：Clinical Infectious Diseases · 年份：2020 · DOI：10.1093/cid/ciaa809 · 被引用次数：31 · 研究领域：HIV Research and Treatment、HIV/AIDS drug development and treatment、HIV/AIDS Research and Interventions

Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.