Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study

作者：Lan Chen, Zhenyu Zhang, Jianguo Fu, Zhipeng Feng, Suzhen Zhang, Qiuying Han, Xiao‐Bin Zhang, Xiong Xiao, Huimin Chen, Li-Long Liu, Xianli Chen, Yu-Pei Lan, De-Jin Zhong, Lan Hu, Junhui Wang, Xinghua Yu, Danyang She, Yong-Hong Zhu, Zhenyu Yin · 发表于：medRxiv · 年份：2020 · DOI：10.1101/2020.06.19.20136093 · 被引用次数：64 · 研究领域：COVID-19 Clinical Research Studies、Sepsis Diagnosis and Treatment、Infectious Encephalopathies and Encephalitis

ABSTRACT The outbreak of novel coronavirus disease 2019 (COVID-19) has become a pandemic. Drug repurposing may represent a rapid way to fill the urgent need for effective treatment. We evaluated the clinical utility of chloroquine and hydroxychloroquine in treating COVID-19. Forty-eight patients with moderate COVID-19 were randomized to oral treatment with chloroquine (1000 mg QD on Day 1, then 500 mg QD for 9 days; n=18), hydroxychloroquine (200 mg BID for 10 days; n=18), or control treatment (n=12). Adverse events were mild, except for one case of Grade 2 ALT elevation. Adverse events were more commonly observed in the chloroquine group (44.44%) and the hydroxychloroquine group (50.00%) than in the control group (16.67%). The chloroquine group achieved shorter time to clinical recovery (TTCR) than the control group (P=0.019). There was a trend toward reduced TTCR in the hydroxychloroquine group (P=0.049). The time to reach viral RNA negativity was significantly faster in the chloroquine group and the hydroxychloroquine group than in the control group (P=0.006 and P=0.010, respectively). The median numbers of days to reach RNA negativity in the chloroquine, hydroxychloroquine, and control groups was 2.5 (IQR: 2.0-3.8) days, 2.0 (IQR: 2.0-3.5) days, and 7.0 (IQR: 3.0-10.0) days, respectively. The chloroquine and hydroxychloroquine groups also showed trends toward improvement in the duration of hospitalization and findings on lung computerized tomography (CT). This study provi...