Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China

作者：Li Liu, Wei Liu, Lulin Nie, Zhiwei Guo, Yi Luo, Weihong Chen, Weimin Liu, Feiqi Zhu, Lu Wang, Jiafei Zhang, Xian Wang, Li Tian, Erwei Gao, Li Zhou, Kaiwu He, Yidan Huang, Chunjie Yuan, Qingqing Zhu, Fang Ye, Xingchen Yu, Jing Yuan, Jianjun Liu · 发表于：BMJ Open · 年份：2020 · DOI：10.1136/bmjopen-2019-034317 · 被引用次数：19 · 研究领域：Chronic Disease Management Strategies、Cardiovascular Health and Risk Factors、Frailty in Older Adults

PURPOSE: The Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders. PARTICIPANTS: The cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district of Shenzhen, China. The baseline data were collected between 2017 and 2018, including demographics and socioeconomics, lifestyles, medical history, family history of major non-communicable chronic disease, environmental exposures, clinical analysis of blood and urine, clinical imaging measurements, anthropometric measures and neurological function and mental health assessments. Blood and urinary samples were collected at baseline. All participants will be followed for physiological and psychological disorders and updated lifestyle and environmental exposures every 5 years. FINDINGS TO DATE: The mean age of the participants was 67.73 years at baseline, and 42.74% were males. The prevalences of individuals with unhealthy conditions were as follows: overweight/obesity (54.38%), hypertension (58.24%), diabetes mellitus (22.30%), dyslipidaemia (75.69%), chronic bronchitis (1.45%), myocardial infarction (0.55%), coronary heart disease (5.69%), stroke (1.10%), cancer (2.18%), arthritis (5.04%), Alzheimer's disease (0.18%), Parkinson's disease (0.23%), brain injury (5.75%), cognitive impairment (5...