<p>The Association Between Serum Thyrotropin Within the Reference Range and Metabolic Syndrome in a Community-Based Chinese Population</p>

作者：Meng Li, Xiuying Zhang, Xianghai Zhou, Xueyao Han, Rui Zhang, Zuodi Fu, Lianying Wang, Ying Gao, Yufeng Li, Linong Ji · 发表于：Diabetes Metabolic Syndrome and Obesity · 年份：2020 · DOI：10.2147/dmso.s252154 · 被引用次数：13 · 研究领域：Thyroid Disorders and Treatments、Marine animal studies overview、Hormonal and reproductive studies

Purpose: We aimed to ascertain the association between thyrotropin (TSH) levels in euthyroid state and the prevalence of metabolic syndrome (MetS) in a community-based Chinese population. Participants and Methods: Based on a large and well-characterized community cohort in Beijing, China, 1831 men and 1742 women with serum TSH levels within the reference range (0.50– 4.78 μIU/mL) were stratified by quartiles of TSH (Q1-4). MetS was identified according to the criteria of International Diabetes Federation guidelines. Poisson regression models were used to estimate the association between serum TSH and the prevalence of MetS and its components before and after adjustment for potential confounding factors. The reported association was measured using the prevalence ratio (PR) with its respective 95% confidence interval (95% CI). Results: The prevalence of MetS in euthyroid population across TSH quartiles (Q1-4) was 38.9%, 44.6%, 41.0%, and 47.7%, respectively, in men ( P = 0.045), and 47.7%, 46.6%, 46.9%, and 54.6%, respectively, in women ( P = 0.032). Compared with the reference group TSH-Q1, the prevalence of MetS was higher among TSH-Q4 group both in men (PR = 1.27; 95% CI: 1.09, 1.48, P = 0.002) and women (PR = 1.21; 95% CI: 1.07, 1.37, P = 0.003) even after adjustment for age, lifestyle factors, serum levels of free triiodothyronine (FT3), and free thyroxine (FT4). Most of the components of MetS were common in higher serum TSH levels within the normal range. Conclusion: The ...