Influences of circulatory factors on intervertebral disc aging phenotype

作者：Changbin Lei, Debora Colangelo, Prashanti Patil, Vivian Li, Kevin Ngo, Dong Wang, Qing Dong, Matthew J. Yousefzadeh, Hongsheng Lin, Joon Lee, James D. Kang, Gwendolyn Sowa, Tony Wyss‐Coray, Laura J. Niedernhofer, Paul D. Robbins, Derek M. Huffman, Nam Vo · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.103421 · 被引用次数：11 · 研究领域：Spine and Intervertebral Disc Pathology、Veterinary Orthopedics and Neurology、Musculoskeletal pain and rehabilitation

). Compared to old isochronic pairs (O-O), old mice paired with young mice (O-Y) exhibited a significant decrease in expression of cellular senescence markers (p16, p21, p53), but only marginal decreases in the levels of disc MMP-13 and ADAMTS4, aggrecan fragmentation, and histologic degeneration. Thus, exposing old mice to young blood circulation greatly suppressed disc cellular senescence, but only slightly decreased disc matrix imbalance and degeneration. Conversely, exposing young mice to old blood accelerated their disc matrix imbalance and tissue degeneration, with little effects on disc cellular senescence. Thus, non-cell autonomous effects of circulating factors on disc cellular senescence and matrix homeostasis are complex and suggest that disc matrix homeostasis is modulated by systemic factors and not solely through local disc cellular senescence.