Prognostic Value of Pre-Treatment Prognostic Nutritional Index in Esophageal Cancer: A Systematic Review and Meta-Analysis

作者：Jianqi Hao, Cong Chen, Fangfang Wan, Yuzhou Zhu, Hongyu Jin, Jian Zhou, Nan Chen, Jing Yang, Qiang Pu · 发表于：Frontiers in Oncology · 年份：2020 · DOI：10.3389/fonc.2020.00797 · 被引用次数：42 · 研究领域：Esophageal Cancer Research and Treatment、Inflammatory Biomarkers in Disease Prognosis、Gastric Cancer Management and Outcomes

Background Prognostic nutritional index, combining albumin and lymphocyte counts, which represents the nutritional and immune status, was considered as a effective predictor for the patient's prognosis after surgery. To comprehensively analyze the relative effectiveness of prognostic performance of pretreatment prognostic nutritional index in esophageal cancer, we performed this meta-analysis. Methods We performed a systemic search in PubMed, EMBASE, CNKI and Web of science. The hazard ratios (HRs) or odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were extracted to explore the correlation between PNI and the postoperative survival of patients with esophageal cancer, including overall survival(OS), recurrence-free survival(RFS) and postoperative complications. The Newcastle-Ottawa Scale(NOS) was applied to estimate the quality of the included studies. The Begg's test was applied to assess the publication bias. Result A total of 13 articles with 3543 patients, were included in our meta-analysis, and 9 studies reported OS in 2731 esophageal cancer patients. The pooled results of the 9 studies suggested that esophageal cancer patients with a low prognostic nutritional index would have a worse overall survival(HR=1.14 95% CI 0.99-1.31 P<0.05). The integrated results also indicated that the prognostic nutritional index was a negative predictor for RFS. Conclusion This meta-analysis indicated a high correlation between PNI and postoperative survival of eso...