BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways

作者：Xingrong Guo, Meng Shan, Yu Huang, Zong Li Zhang, Yue Yuan, Long Dai, Jue Wang, Xue Zhou, Fu Yun Ji, Jun Tang, Zhong Ji Meng, Xu Zhi Ruan · 发表于：Signal Transduction and Targeted Therapy · 年份：2020 · DOI：10.1038/s41392-020-0189-8 · 被引用次数：9 · 研究领域：Cell Adhesion Molecules Research、Protein Degradation and Inhibitors、Peptidase Inhibition and Analysis

BARMR1 (alternatively named FAM92A1 or FAM92A) gene was first identified in 2002 and is a highly conserved gene and widely expressed in most tissues in mammals. 1 We first cloned the complete CDS sequence of BARMR1 in 2007, 2 which encodes a protein with a Bin-Amphiphysin-Rvs (BAR) domain. BAR-containing proteins are known to bind onto lipid membrane surface and generate membrane curvature and have been demonstrated to play diverse roles in cell growth, inflammation and cell migration. 3