Phytochemical Curcumin-Coformulated, Silver-Decorated Melanin-like Polydopamine/Mesoporous Silica Composites with Improved Antibacterial and Chemotherapeutic Effects against Drug-Resistant Cancer Cells

作者：Yiyan Song, Ling Cai, Zhongcheng Tian, Yuan Wu, Jin Chen · 发表于：ACS Omega · 年份：2020 · DOI：10.1021/acsomega.0c00912 · 被引用次数：65 · 研究领域：Curcumin's Biomedical Applications、Polydiacetylene-based materials and applications、Dendrimers and Hyperbranched Polymers

High Resolution Image Download MS PowerPoint Slide The devastating occurrence of drug resistance such as antimicrobial resistance has aroused global concerns for public health, which has propelled a continuous pursuit of safe and effective therapeutic agents. In this study, silver nanoparticles were decorated in mesoporous silica of SBA-15 coated with melanin-like polydopamine (PDA) as nanocarriers. Meanwhile, the constructed mesopore was loaded with phytochemical curcumin (CCM) through its noncovalent interactions with PDA coatings. The obtained [email protected] /PDA/Ag composites were characterized by physicochemical methods and exhibited desirable biocompatibility and low hemolytic activity. The dual-stimuli-responsive (pH and ROS) release of curcumin and/or silver nanoparticles from the [email protected] /PDA/Ag composites was achieved to reduce the side effects of noncontrolled drug leakage under physiological conditions. Additionally, compared with that of SBA-15/PDA/Ag and [email protected] /PDA, [email protected] /PDA/Ag combination showed a prolonged inhibitory effect on bacterial growth of G – E. coli (72 h) and G + S. aureus (24 h), attributing to the enhanced effect of the bactericide of silver nanoparticles and curcumin. Furthermore, through the utilization of the nanoformulation of curcumin, improved chemotherapeutic efficiency against human cervical cancer cells (HeLa) and Taxol-resistant nonsmall cell lung cells (A549/TAX) was identified in comparison with th...