Prospective study of pregnancy outcome between perceived stress and stress‐related hormones

作者：Yuqian Cui, Hongling Yu, Fanwei Meng, Jin Liu, Fang Yang · 发表于：Journal of obstetrics and gynaecology research · 年份：2020 · DOI：10.1111/jog.14278 · 被引用次数：15 · 研究领域：Reproductive Health and Technologies、Ovarian function and disorders、Reproductive Health and Contraception

AIM: To evaluate the relationship between physiological and psychological stress on pregnancy outcome in women undergoing in vitro fertilization-embryo transfer (IVF-ET) treatment. METHODS: Women undergoing the first IVF cycle were enrolled to complete the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS). Their blood samples were collected on the 3rd day of the menstrual cycle to measure 5-hydroxytryptamine, renin, norepinephrine, angiotensin II and cortisol. Salivary amylase was obtained on the embryo transfer day. RESULTS: Compared with normal women who came to the hospital for regular physical examination, the incidence of anxiety and depression was higher in women seeking for IVF treatment. After psychological intervention, the condition got improved and the incidence of anxiety and depression was 6.25% and 7.81% separately in these women. There were no significant differences between the anxiety scores in women with and without pregnancy. The depression scores did show some statistically differences, with higher scores in the nonpregnancy group. The level of 5-hydroxytryptamine, renin, norepinephrine and cortisol were not significantly different between the two groups, while angiotensin II and salivary amylase seemed to be negatively correlated with pregnancy outcome. Simultaneously, a positive correlation was found between angiotensin II and anxiety and depression scores. CONCLUSION: Depression during IVF has a negative impact on pregnancy outc...