CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats

作者：Yoshio Ogura, Munehiro Kitada, Jing Xu, Itaru Monno, Daisuke Koya · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.103410 · 被引用次数：121 · 研究领域：Calcium signaling and nucleotide metabolism、Adenosine and Purinergic Signaling、Sirtuins and Resveratrol in Medicine

/NADH ratio and Sirt3 activity in renal proximal tubular HK-2 cells cultured under high-glucose conditions. Together, these results demonstrate that by inhibiting the Sirt3 activity and increasing mitochondrial oxidative stress in renal tubular cells, CD38 plays a crucial role in the pathogenesis of DKD.