Altered Composition of Gut Microbiota in Depression: A Systematic Review

作者：Zahra Amirkhanzadeh Barandouzi, Angela Starkweather, Wendy A. Henderson, Adwoa Gyamfi, Xiaomei Cong · 发表于：Frontiers in Psychiatry · 年份：2020 · DOI：10.3389/fpsyt.2020.00541 · 被引用次数：477 · 研究领域：Gut microbiota and health、Diet and metabolism studies、Tryptophan and brain disorders

Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature search of human studies, published between January 2000 to June 2019 were reviewed. The key words included gastrointestinal microbiome, gut microbiome, microbiota, depression, depressive symptoms and depressive disorder. The systematic review adhered to the Preferred Reporting Items for systematic Reviews and Meta-Analysis (PRISMA) guidelines. Nine articles met the eligibility criteria. Disparities in α-diversity and β-diversity of the microbiota existed in people with depression compared to healthy controls. At the phylum level, there were inconsistencies in the abundance of Firmicutes, Bacteroidetes and Proteobacteria. However, high abundance in Actinobacteria and Fusobacteria phyla were observed in people with depression. On the family level, high abundance of Actinomycineae, Coriobacterineae, Bifidobacteriaceae, Clostridiales incertae sedis XI, Porphyromonadaceae, Clostridiaceae, Lactobacillaceae, Streptococcaceae, Eubacteriaceae, Thermoanaerobacteriaceae, Fusobacteriaceae, Nocardiaceae, Streptomycetaceae, and low abundance of Veillonellaceae, Prevotellaceae, Bacteroidaceae, Sutterellaceae, Oscillospiraceae, Marniabilaceae and Chitinophagaceae were observed in people with depr...