Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging

作者：Shuhua Shen, Chao Li, Luwei Xiao, Xiaoming Wang, Hang Lv, Yuan Shi, Yixue Li, Qi Huang · 发表于：Human Genomics · 年份：2020 · DOI：10.1186/s40246-020-00271-7 · 被引用次数：14 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Epigenetics and DNA Methylation、Single-cell and spatial transcriptomics

BACKGROUND: Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research. METHODS: We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity. RESULTS: Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overrepresented. CONCLUSIONS: Our study indicated a new mechanism of longevity, suggesting potential genetic variants for further study.