Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population

作者：Li Jiang, Yongtong Cao, Cheng Xiao · 发表于：Lipids in Health and Disease · 年份：2020 · DOI：10.1186/s12944-020-01314-7 · 被引用次数：15 · 研究领域：Dementia and Cognitive Impairment Research、Nutritional Studies and Diet、Fatty Acid Research and Health

BACKGROUND: Previous studies reported that the association between lipid levels and cognitive function is related with gender, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered interest in exploring how serum lipids relate to cognitive function in different subgroups. METHODS: Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level. RESULTS: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β ± SE: 2.06 ± 0.88, P = 0.023) and obese (β ± SE: 1.44 ± 0.71, P = 0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β ± SE: 1.89 ± 0.92, P = 0.041) and obese (β ± SE: 5.04 ± 1.62, P = 0.002) female group. Serum TC was negatively associated with cognitive function score in overweight (β ± SE: - 2.55 ± 1.26, P = 0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overw...