Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis

作者：Derek K. Chu, Elie A Akl, Stephanie Duda, Karla Solo, Sally Yaacoub, Holger J. Schünemann, Derek K. Chu, Elie A. Akl, Amena El‐Harakeh, Antonio Bognanni, Tamara Lotfi, Mark Loeb, Anisa Hajizadeh, Anna Bąk, Ariel Izcovich, Carlos A. Cuello‐García, Chen Chen, David J. Harris, E Borowiack, Fatimah Chamseddine, Finn Schünemann, Gian Paolo Morgano, Giovanna E.U. Muti Schünemann, Guang Chen, Hong Zhao, Ignacio Neumann, Jeffrey Shi Kai Chan, Joanne Khabsa, Layal Hneiny, Leila Harrison, Maureen Smith, Nesrine Rizk, Paolo Giorgi Rossi, Pierre Abihanna, Rayane El-Khoury, Rosa Stalteri, Tejan Baldeh, Thomas Piggott, Yuan Zhang, Zahra Saad, Assem M. Khamis, Marge Reinap, Stephanie Duda, Karla Solo, Sally Yaacoub, Holger J. Schünemann · 发表于：The Lancet · 年份：2020 · DOI：10.1016/s0140-6736(20)31142-9 · 被引用次数：4105 · 研究领域：Infection Control and Ventilation、Retinal and Optic Conditions、COVID-19 epidemiological studies

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is spread personto-person through close contact.We aimed to investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings. MethodsWe did a systematic review and meta-analysis to investigate the optimum distance for avoiding person-toperson virus transmission and to assess the use of face masks and eye protection to prevent transmission of viruses.We obtained data for SARS-CoV-2 and the betacoronaviruses that cause severe acute respiratory syndrome, and Middle East respiratory syndrome from 21 standard WHO-specific and COVID-19-specific sources.We searched these data sources from database inception to May 3, 2020, with no restriction by language, for comparative studies and for contextual factors of acceptability, feasibility, resource use, and equity.We screened records, extracted data, and assessed risk of bias in duplicate.We did frequentist and Bayesian meta-analyses and random-effects metaregressions.We rated the certainty of evidence according to Cochrane methods and the GRADE approach.This study is registered with PROSPERO, CRD42020177047.Findings Our search identified 172 observational studies across 16 countries and six continents, with no randomised controlled trials and 44 relevant comparative studies in health-care and non-health-care settings (n=25 697 patients).Transmission of ...