Research progress on targeting bone marrow microenvironment in acute leukemia therapy

作者：Huiting Huang, Qi Peng, Ping-Fang Xia, Shanshan Wei, Qian Li, Miaorong She · 年份：2016 · DOI：10.3760/cma.j.issn.1673-419x.2016.02.008 · 研究领域：Acute Myeloid Leukemia Research、Immune cells in cancer、Hematopoietic Stem Cell Transplantation

Acute leukemia (AL) is a kind of malignant clonal disease initiated by leukemia stem cells (LSC) with a high mortality. Although combined chemotherapy and hematopoietic stem cell transplantation significantly improved the complete remission rate and overall survival in AL patients, chemoresistance and relapse are still great challenges. Recently, increasing results of studies showed that LSC protected by bone marrow microenvironment was responsible in part of for AL relapse and chemoresistance. LSC hide in the bone marrow microenvironment to escape the killing of chemotherapy drugs and remain self-renewal ability. Furthermore, LSC also promote leukemogenesis by modulating the bone marrow microenvironment. Taken together, targeting the interaction between bone marrow microenvironment and LSC may provide a new promising and novel therapeutic strategies for curing AL. Key words: Cellular microenvironment; Leukemia; Stem cells, Leukemia; Molecular targeted therapy