Rosette Trajectories Enable Ungated, Motion‐Robust, Simultaneous Cardiac and Liver T 2 * Iron Assessment

作者：Adam Bush, Christopher M. Sandino, Shreya Ramachandran, Frank Ong, Nicholas Dwork, Evan J. Zucker, Ali Syed, John M. Pauly, Marcus T. Alley, Shreyas Vasanawala · 发表于：Journal of Magnetic Resonance Imaging · 年份：2020 · DOI：10.1002/jmri.27196 · 被引用次数：12 · 研究领域：Advanced MRI Techniques and Applications、Cardiac Imaging and Diagnostics、MRI in cancer diagnosis

Background Quantitative T 2 * MRI is the standard of care for the assessment of iron overload. However, patient motion corrupts T 2 * estimates. Purpose To develop and evaluate a motion‐robust, simultaneous cardiac and liver T 2 * imaging approach using non‐Cartesian, rosette sampling and a model‐based reconstruction as compared to clinical‐standard Cartesian MRI. Study Type Prospective. Phantom/Population Six ferumoxytol‐containing phantoms (26–288 μg/mL). Eight healthy subjects and 18 patients referred for clinically indicated iron overload assessment. Field Strength/Sequence 1.5T, 2D Cartesian and rosette gradient echo (GRE) Assessment GRE T 2 * values were validated in ferumoxytol phantoms. In healthy subjects, test–retest and spatial coefficient of variation (CoV) analysis was performed during three breathing conditions. Cartesian and rosette T 2 * were compared using correlation and Bland–Altman analysis. Images were rated by three experienced radiologists on a 5‐point scale. Statistical Tests Linear regression, analysis of variance (ANOVA), and paired Student's t ‐testing were used to compare reproducibility and variability metrics in Cartesian and rosette scans. The Wilcoxon rank test was used to assess reader score comparisons and reader reliability was measured using intraclass correlation analysis. Results Rosette R2* (1/T 2 *) was linearly correlated with ferumoxytol concentration (r 2 = 1.00) and not significantly different than Cartesian values ( P = 0.16). Duri...